منابع مشابه
Synthesis and anticonvulsant evaluation of some novel 2,5-disubstituted 1,3,4-thiadiazoles: pharmacophore model studies.
A novel series of N'-{5-[(1H-indol-3-ylmethyl)-1,3,4-thiadiazol-2-yl}-N4-(4-substituted benzaldehyde)-semicarbazones, N1-{5-[(1H-indol-3-ylmethyl)-1,3,4-thiadiazol-2-yl}-N4-[1-(4-substituted phenyl)ethanone]-semicarbazones and N1-{5-[(1H-indol-3-ylmethyl)-1,3,4-thiadiazol-2-yl}-N4-[1-(4-substituted phenyl) (phenyl) methanone]-semicarbazones were synthesized and evaluated for their anticonvulsan...
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N-hydroxyethyl phthalimide (PE-I) was prepared by refluxing phthalic anhydride with ethanolamine. 3phthalimidoethyl substituted benzoic acids (PE-II) were prepared by refluxing N-hydroxyethyl phthalimide with substituted benzoic acids. The corresponding acid chlorides (PE-III) were condensed with benzilidine-4acetophenone derivatives to afford the 3-(phthalimidoethyl)-4-substituted cinnamoyl su...
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Thiadiazole and their derivatives have been studied extensively because of their wide range of biological activity. They are found to be effective as antibacterial, antimalarial, antiviral, antiinflammatory, anticancer and antianthelminthic agents. Diverse biological activities, such as antibacterial, anti-inflammatory, and antiviral have been associated with 1,3,4Thiadiazole derivatives. The s...
متن کاملSynthesis and antimicrobial activity of some new 1,3,4-thiadiazoles and 1,3,4-thiadiazines containing 1,2,4-Triazolo nucleus.
The desired fused ring system 3-(3-chlorophenyl)-6-aryl-5,6-dihydro[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a-j were synthesized by the reaction of 4-amino-5-(3-chlorophenyl)-4H-1,2,4-triazole-3-thiol and different aryl aldehydes in the presence of catalytic amount of p-TsOH in dry DMF, while 3-(3-chlorophenyl)-6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines 7a-j were synthesized by using...
متن کاملSynthesis of some new 2,5-disubstituted 1,3,4-thiadiazoles containing isomeric pyridyl as potent antimicrobial agents.
Several new 2,5-disubstituted derivatives of 1,3,4-thiadiazoles containing isomeric pyridyl were obtained from cyclization of corresponding thiosemicarbazides under acidic conditions. The newly synthesized compounds were characterized using different methods of spectroscopy such as IR, 1H-NMR, 13C-NMR, MS and elemental analysis. The minimal inhibitory concentration (MIC) results of screening of...
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ژورنال
عنوان ژورنال: Canadian Journal of Chemistry
سال: 1959
ISSN: 0008-4042,1480-3291
DOI: 10.1139/v59-165